Kyle Giesler, Ph.D. Candidate
Kyle Giesler is a technical specialist at Knowles IP Strategies, LLC. He is also currently a fourth year graduate student at Emory University pursuing his Ph.D in Organic Chemistry in the laboratory of Professor Dennis C. Liotta, the Samuel Chandler Dobbs Professor of Chemistry, an internationally acknowledged leader in academic drug discovery.
During his doctoral research at Emory, Kyle developed a novel and relatively non-toxic prodrug strategy for tenofovir, adefovir, and other antiviral nucleosides to furnish nucleoside conjugates that demonstrate sub-nanomolar anti-HIV activity and increase the therapeutic index in excess of 100,000, which rivals well-accepted conjugation strategies. Emory University has filed a patent application on this work, which will be published in the scientific literature in 2016. In addition, Kyle has initiated a collaboration between Emory University and Morehouse School of Medicine to study the relationship between CXCR4 and the HIV protein Nef, developed acyclic nucleoside analogs for the treatment of chronic viral infections and cancer, and holds the Emory Graduate Diversity Fellowship awarded to outstanding graduate students that demonstrate academic excellence and “show exceptional promise as future leaders in their fields”.
Prior to Emory, Kyle graduated cum laude from the University of Central Florida (UCF) with a B.S in chemistry and a minor in mathematics. At UCF, Kyle was heavily involved in undergraduate research under Professor Richard Blair that focused on the mechanochemical synthesis of isomorphously substituted kaolinite clays and received first place at the Student Undergraduate Research Experience (SURE) in 2011. This work and others yielded three research publications during Kyle’s time as an undergraduate researcher for which he received the departmental “Outstanding Young Inorganic Chemist” award and an NSF-sponsored EXCEL scholarship.